BMSC 666 Chemical Biology Innovators

Credits: 2
The 2-credit (6 week; 4 h/week) course will provide a broad overview of the field of chemical biology. The focus will be on chemistry-mediated innovations that enable new biological discoveries. Topics will include:

Lighting up Biology (GFP, small molecule probes);
Analyzing enzyme classes (activity-based protein profiling);
Metabolic engineering (bioorthogonal chemistry, unnatural amino acids);
Imparting new functions on proteins (directed evolution);
Controlling enzymes (Photopharmacology, PROTAC) and
Chemical Genetics.

Each lecture will highlight a leader in the field and her/his seminal papers. Grades will be based on: Course participation (25%); Paper reviews/commentaries (40%); Pre-proposal pitch (5%); Original research proposal (25%); presentation of proposal (5%).

Graded: A-F
May be taken only once for credit