CELL 665 Development, Differentiation, and Disease

Credits: 3
Orchestration of development requires precise timing, spatial coordination, and reciprocal signaling between cells to result in proper tissue generation and remodeling. Disruption of these normal cellular homeostatic mechanisms occurs in a number of diseases including cancer and in many cases has led to discoveries about the function of normal genes and interacting signaling pathways in development. In this class, mechanisms of growth and development of higher eukaryotes are covered, including important signaling events, pattern formation and cell movements resulting in the fully differentiated tissues and organisms. Consideration will be given to how stem cell population are positioned and maintained, as well as mechanisms that underlie the maintenance and function of individual tissues in the fully developed organism. Moreover, aberrations in these events are covered relative to their underlying contributions to the etiology and progression of specific disease and cancers.

Graded: A-F
May be taken only once for credit