HIP 514 Molecular & Cellular Approaches to Disease

Credits: 1.5
The power of contemporary methods in molecular and cell biology to reveal complex mechanisms of pathogenesis has increased geometrically. With completion of the human genome project, and with new technologies for genomic screening and bioinformatics, clinician scientists have unique opportunities to rapidly define pathways of disease pathogenesis. They must be well trained in fundamental concepts of basic research technologies in fields of molecular and cell biology, biochemistry and molecular pharmacology. Similarly, basic researchers require training in clinical research methods and translational study design. The lectures review important molecular, cellular and biological approaches frequently encountered with an emphasis on how these can be applied clinical studies. The objectives are to provide a fully integrated experience for both basic and clinician scientists in fundamentals of translational clinical research with examples from successful research projects. Three conceptually linked strategies are used:

lectures covering experimental approaches to translational projects,
in-class participation in topical discussions, and
project development in trainee’ area of interest utilizing the methodologies covered in the course.

This course is taught by clinician scientists with expertise in applying molecular biology to translational research, which allows for clinical correlation and application of the subject matter. Specific topics may include genetic and genomic technologies, use of animal models, use of bioregistries, basic and clinical cancer research, approaches to infectious diseases, auditory disorders, sleep physiology, cardiorenal medicine and gene therapy, study design and statistical considerations.

Graded: Pass/No pass
May be taken only once for credit